Reynolds Risk Score Calculator

Reynolds Risk Score Calculator for Cardiology. This models a composite cardiovascular endpoint, not just myocardial infarction. The prior demonstration percentage has been removed. HbA1c is never used here to infer a diabetes diagnosis; the diabetes selector determines whether its term is applicable.

For shared guidance on choosing a tool and documenting results, read the clinical calculator workflow.

How this calculator works

The tool independently implements the published 2007 women's model B, using natural logarithms of systolic pressure, hsCRP and cholesterol concentrations in mg/dL. B = 0.0799 x age + 3.137 x ln(SBP) + 0.180 x ln(hsCRP) + 1.382 x ln(TC) - 1.172 x ln(HDL), plus 0.818 for smoking, 0.438 for parental MI before 60, and 0.134 x HbA1c only with known diabetes. Risk = 100 x [1 - 0.98634^exp(B - 22.325)].

When to use this calculator

Historical primary-prevention model comparison for women without established cardiovascular disease. It is not the male Reynolds equation, PREVENT or an official Reynolds software product.

Inputs used

  • Established diabetes status
  • Age (45-80 years in this implementation)
  • Systolic pressure (mmHg)
  • hsCRP (mg/L, strictly positive)
  • Total and HDL cholesterol (mmol/L or mg/dL)
  • HbA1c (%) only with known diabetes
  • Current smoking
  • Parental MI before age 60

Clinical interpretation

This models a composite cardiovascular endpoint, not just myocardial infarction. The prior demonstration percentage has been removed. HbA1c is never used here to infer a diabetes diagnosis; the diabetes selector determines whether its term is applicable.

Worked example

The paper's 50-year-old smoking woman without diabetes, with SBP 155, total cholesterol 240 mg/dL, HDL 35 mg/dL, hsCRP 0.1 mg/L and no parental history, produces about 4.9% over ten years. With hsCRP 20 and parental history, the estimate is about 18.4%.

Limitations and safety notes

The original cohort was predominantly White female health professionals. Calibration in other populations and current practice is uncertain. Age 45-80 and laboratory bounds are implementation restrictions, not proven validation boundaries. A zero hsCRP cannot enter a logarithm. Acute inflammation can make hsCRP unrepresentative. No treatment threshold or clinician signoff is claimed.

Frequently asked questions

Why is HbA1c hidden without diabetes?

The published model adds HbA1c only when diabetes is already established. It is not a universal model term.

Why can a result differ from Table 6 in the paper?

Two printed cells do not round from the published model B coefficients: parental-history cases at hsCRP 3 and 5 give 13.4597% and 14.6561%, while the table lists 13.4% and 14.6%. This tool follows the printed equation and documents the discrepancy; the reason is not established.

Are these the official Reynolds website calculations?

No. This is an independently written implementation of the published female equation, with explicit input restrictions; no official software or licensing endorsement is claimed.

References

  • Ridker PM et al. Development and Validation of Improved Algorithms for the Assessment of Global Cardiovascular Risk in Women: The Reynolds Risk Score. JAMA 2007, model B and Table 6. https://jamanetwork.com/journals/jama/fullarticle/205528
  • AHA/ACC et al. Dyslipidemia guideline 2026: contemporary risk and lipid-management context. https://doi.org/10.1161/CIR.0000000000001423

Editorial review and citation methodology

Maintained by the Quick Medical Calculator Editorial Team. Content record date: September 9, 2026. A content date is not evidence of independent clinical review. Individual clinical sign-off is not recorded on this page.

  • Prefer original validation studies for scoring systems and prediction tools.
  • Use current specialty society guidance, transplant allocation policy, public health guidance, or regulator resources when they govern clinical use.
  • Include limitations and safety notes when a calculator is population-specific, context-dependent, or unsuitable as a standalone decision tool.

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