eGFR (CKD-EPI 2021) Calculator

How this calculator works

The CKD-EPI 2021 creatinine equation estimates glomerular filtration rate from serum creatinine, age, and sex without a race coefficient.

Inputs used

• Serum creatinine
• Age
• Sex

Clinical interpretation

Use eGFR to stage chronic kidney disease, trend kidney function, and inform drug dosing discussions. Confirm chronicity with repeat testing and albuminuria assessment.

Limitations and safety notes

Creatinine-based eGFR is less reliable with rapidly changing kidney function, extremes of muscle mass, pregnancy, amputations, severe malnutrition, and some medications or assay issues.

References

• Inker LA, Eneanya ND, Coresh J, et al. New creatinine- and cystatin C-based equations to estimate GFR without race. N Engl J Med. 2021.
• KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease.

Editorial review and citation methodology

Reviewed by the Quick Medical Calculator Editorial Team. Last reviewed: June 19, 2026. The review checks calculator inputs, intended population, interpretation, limitations, and source alignment.

• Prefer original validation studies for scoring systems and prediction tools.
• Use current specialty society guidance, transplant allocation policy, public health guidance, or regulator resources when they govern clinical use.
• Include limitations and safety notes when a calculator is population-specific, context-dependent, or unsuitable as a standalone decision tool.