High Dose Insulin Euglycemia Therapy (HIET) Calculator

High Dose Insulin Euglycemia Therapy (HIET) Calculator for Endocrinology. Units/hour and mL/hour are different quantities and must agree with the actual preparation. The displayed bolus volume assumes the same concentration as the infusion; a separately prepared bolus needs a separate check. Zero bolus or infusion coefficients produce zero quantities.

For shared guidance on choosing a tool and documenting results, read the clinical calculator workflow.

How this calculator works

This prescribed-order arithmetic tool multiplies weight by the entered infusion coefficient to obtain units/hour, then divides by the entered concentration for mL/hour. It separately multiplies weight by the prescribed bolus coefficient and converts that quantity to mL of the same preparation. No regimen is selected automatically.

When to use this calculator

Use for an independent arithmetic cross-check within a resuscitation, toxicology and pharmacy-supervised plan. AHA 2025 addresses high-dose insulin for selected serious beta-blocker or calcium-channel-blocker poisoning. This page does not determine eligibility, replace poison-center advice or supply the accompanying monitoring protocol.

Inputs used

  • Weight in kg or lb
  • Prescribed bolus coefficient in units/kg, zero if omitted
  • Prescribed infusion coefficient in units/kg/hour
  • Prepared insulin concentration in units/mL

Clinical interpretation

Units/hour and mL/hour are different quantities and must agree with the actual preparation. The displayed bolus volume assumes the same concentration as the infusion; a separately prepared bolus needs a separate check. Zero bolus or infusion coefficients produce zero quantities.

Worked example

With 80 kg, prescribed bolus 1 unit/kg, infusion 0.5 units/kg/hour and prepared concentration 10 units/mL, the infusion is 40 units/hour or 4 mL/hour. The bolus is 80 units or 8 mL of that preparation. These are hypothetical prescribed values, not a recommended starting regimen.

Limitations and safety notes

Glucose and potassium monitoring, dextrose provision, hemodynamic response, titration and formulation verification are outside the calculation. Hypoglycemia, electrolyte shifts and fluid load are important risks. Entry limits are not protocol ceilings or recommended doses. Decimal arithmetic does not authorize a pump setting.

Frequently asked questions

Does the calculator choose a HIET protocol?

No. Enter only prescribed coefficients and the verified preparation concentration. The linked guideline provides clinical context, not an automatically applied regimen.

Why must concentration be entered?

The same units/hour can require very different pump rates. A wrong concentration can produce a major medication error even when weight-based multiplication is correct.

References

  • 2025 AHA primary special-circumstances resuscitation guidance; high-dose insulin in selected beta-blocker/calcium-channel-blocker poisoning and metabolic monitoring risks. No dosing table reproduced. https://cpr.heart.org/en/resuscitation-science/cpr-and-ecc-guidelines/adult-and-pediatric-special-circumstances-of-resuscitation

Editorial review and citation methodology

Maintained by the Quick Medical Calculator Editorial Team. Content record date: September 9, 2026. A content date is not evidence of independent clinical review. Individual clinical sign-off is not recorded on this page.

  • Prefer original validation studies for scoring systems and prediction tools.
  • Use current specialty society guidance, transplant allocation policy, public health guidance, or regulator resources when they govern clinical use.
  • Include limitations and safety notes when a calculator is population-specific, context-dependent, or unsuitable as a standalone decision tool.

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