Neutropenia Risk Calculator

Neutropenia Risk Calculator for Oncology. Zero is class I, 1-2 class II and 3-8 class III. These categories describe relative complication risk within the studied context; no individual complication percentage is assigned. Even class I cannot exclude serious complications or authorize discharge.

For shared guidance on choosing a tool and documenting results, read the clinical calculator workflow.

How this calculator works

The 2015 CISNE score adds 2 for ECOG at least 2, 1 each for COPD, chronic cardiovascular disease, NCI mucositis at least grade 2 and monocytes below 200 cells/uL, and 2 for assessed stress hyperglycemia. Total range is 0-8. Every factor needs an answer; missing findings do not become zero.

When to use this calculator

Only after assessing an apparently stable adult with a solid tumor and established febrile neutropenia after conventional chemotherapy, beginning outside hospital. This implementation excludes hematologic malignancies, transplantation and intensive chemotherapy. Instability, organ dysfunction or major infection bypasses the score.

Inputs used

  • Confirmed adult solid-tumor outpatient-onset febrile neutropenia after conventional chemotherapy
  • Clinical stability established by assessment, without a separate urgent admission indication
  • Assessed ECOG performance status and NCI/CTCAE v3 oral mucositis grades
  • Explicit clinical history of COPD and chronic cardiovascular disease
  • Absolute monocyte count in cells/uL, not a differential percentage
  • Stress-induced hyperglycemia assessed clinically with competing causes excluded

Clinical interpretation

Zero is class I, 1-2 class II and 3-8 class III. These categories describe relative complication risk within the studied context; no individual complication percentage is assigned. Even class I cannot exclude serious complications or authorize discharge.

Worked example

In a fictional eligible stable episode, ECOG 2 contributes 2 points and monocytes 150 cells/uL contribute 1. With no other factors, 2 + 1 = 3, class III. If the monocyte count is exactly 200, it contributes zero and the total becomes 2, class II.

Limitations and safety notes

This is not prediction of chemotherapy-induced neutropenia, a fever diagnosis or an antibiotic plan. FINITE used CTCAE v3 mucositis and defined stress hyperglycemia by glucose at least 121 mg/dL, or 250 with diabetes, after excluding other causes. The component records that clinical assessment rather than diagnosing it from glucose alone. Repeat clinical assessment remains essential; source verification is not independent clinical validation.

References

  • Carmona-Bayonas A et al. Prospective FINITE validation of CISNE. J Clin Oncol 2015. https://pubmed.ncbi.nlm.nih.gov/25559804/
  • SEOM. Original FINITE study protocol, version 4.0 (2012), pages 13, 15-16 and 19. https://seom.org/seomcms/images/stories/recursos/infopublico/publicaciones/FINITE_v5_duplex-rev.pdf

Editorial review and citation methodology

Maintained by the Quick Medical Calculator Editorial Team. Content record date: September 9, 2026. A content date is not evidence of independent clinical review. Individual clinical sign-off is not recorded on this page.

  • Prefer original validation studies for scoring systems and prediction tools.
  • Use current specialty society guidance, transplant allocation policy, public health guidance, or regulator resources when they govern clinical use.
  • Include limitations and safety notes when a calculator is population-specific, context-dependent, or unsuitable as a standalone decision tool.

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